Endocrine Abstracts

Background and Objective: Congenital adrenal hyperplasia (CAH) is one of the most common diseases in pediatric endocrinology. Non-classical (NC-CAH) forms are characterized by milder enzyme dysfunction and manifests commonly in adolescence or adulthood. The most frequent form of NC-CAH occurs due to 21-hydroxylase deficiency which is caused by defects in the CYP21A2 gene. Our aim was to describe the most common 21-hydroxylase gene (CYP21A2) mutations in our geographical area i...

Objetive: Obesity is associated with lower serum vitamin D (25(OH)D3) levels through several mechanisms. The aim of the study was to determine the prevalence of vitamin D deficiency and to examine the association between insulin resistance and 25(OH)D3 levels in a cohort of obese subjects.Materials and methods: 85 obese subjects were enrolled into the study from october to december 2018. Demographic, anthropometric and clinical para...

Objective: SGLT2 inhibitors, have been shown to improve glycaemic control, stabilize insulin dosing and mitigate insulin-associated weight gain in patients whose type 2 diabetes mellitus (T2DM) was inadequately controlled. The objective is to evaluate the real-world efficacy and safety of adding iSGLT-2 therapy in inadequately controlled patients with oral antidiabetic drugs and with or without insulin therapy.Materials and methods: This observational st...